Histochemical Study of Hydroxysteroid Dehydrogenase in Human Placenta
نویسندگان
چکیده
منابع مشابه
-Hydroxysteroid Dehydrogenase in Human Aorta
3 -hydroxysteroid dehydrogenase (3 -HSD) is known to be involved in steroid production and/or metabolism and to be expressed in many tissues including adrenal cortex. Expression of this enzyme has also been elucidated in human cardiovascular system but its details remain largely unknown. Therefore, in this study, we examined the status of 3 -HSD in postmortem human aorta utilizing RT-PCR and im...
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Cortisol reduces the activity of the PG-inactivating enzyme 15-hydroxyprostaglandin dehydrogenase (PGDH) in human placental cells. The objective was to investigate a possible relation between 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2), converting cortisol to cortisone, and PGDH gene expression in the placenta of patients with preeclampsia. In placental tissue taken from 20 healthy...
متن کامل11Beta-hydroxysteroid dehydrogenase type II and mineralocorticoid receptor in human placenta.
In mineralocorticoid target organs, 11beta-hydroxysteroid dehydrogenase type II (11beta-HSD2) confers specificity on the mineralocorticoid receptor (MR) by converting biologically active glucocorticoids to inactive metabolites. Placental 11beta-HSD2 is also thought to protect the fetus from high levels of circulating maternal glucocorticoid. In this study, we examined the immunoreactivity of 11...
متن کاملPurification of a 17beta-hydroxysteroid dehydrogenase of human placenta and studies on its transhydrogenase function.
This paper describes methods for the extensive purification of a soluble 17@-hydroxysteroid dehydrogenasel of human placenta. This single enzyme appears to be responsible for the entire 17/3estradiol-mediated transfer of hydrogen between pyridine nucleotides in soluble extracts of this tissue. Experiments which were reported in 1958 (2, 3) showed that soluble enzyme preparations derived from hu...
متن کاملPurification of 11β-hydroxysteroid dehydrogenase type 2 from human placenta utilizing a novel affinity labelling technique
11β-Hydroxysteroid dehydrogenase type 2 (11β-HSD2) efficiently inactivates potent glucocorticoid hormones (cortisol and corticosterone), leaving aldosterone unmetabolized. Abundant 11β-HSD2 activity in human placenta plays a central role in controlling fetal glucocorticoid exposure, which if excessive is harmful and may predispose to low birth weight and hypertension in adulthood. Similar 11β-H...
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ژورنال
عنوان ژورنال: Okayama Igakkai Zasshi (Journal of Okayama Medical Association)
سال: 1969
ISSN: 0030-1558,1882-4528
DOI: 10.4044/joma1947.81.5-6_295